Consumer Medicine Information
Neulastim®
pegfilgrastim
6 mg of pegfilgrastim in 0.6 mL (10 mg/mL) solution for injection
What is in this leaflet
牟凤彬This leaflet answers some common questions about NEULASTIM.
It does not contain all the available information.
It does not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking NEULASTIM against the benefits expected for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.宋茜尼坤最新消息
What NEULASTIM is used for
NEULASTIM solution for injection contains the active ingredient pegfilgrastim.
Using gene technology, pegfilgrastim is produced in a specific type of bacteria, li.
Pegfilgrastim is a long-acting form of recombinant human Granulocyte Colony Stimulating Factor (G-CSF).G-CSF is produced by the body in the bone marrow and assists in the production of neutrophils, which are a type of white blood cell.Neutrophils defend the body against infection by destroying bacteria in the blood.
NEULASTIM also helps neutrophils to be more effective.
Some chemotherapy medicines will reduce the number of neutrophils in your body. Although NEULASTIM is not a treatment for cancer,it is used following chemotherapy to increase the number of neutrophils.This will reduce your chance of developing infections that might require treatment with antibiotics and/or hospital stays. NEULASTIM may also help to keep your chemotherapy treatment on schedule.
NEULASTIM does not cure the underlying illness but it is an important supportive therapy.
Your doctor, however, may have prescribed NEULASTIM for another purpose.
Ask your doctor if you have any questions about why NEULASTIM has been prescribed for you.
This medicine is available only with a doctor’s prescription.
Before you use NEULASTIM
When you must not use it
Do not use NEULASTIM if:
ZARZIO®) and have had an allergic reaction to pegfilgrastim, filgrastim or any ingredients listed at the end of this leaflet
technology using the li
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This is because the chemotherapy medicine may stop NEULASTIM from increasing the number of infection-fighting neutrophils.
5.the package is torn or shows signs of tampering
6.the expiry date printed on the pack has passed
If you take this medicine after the expiry date has passed, it may not work as well.
7.the medicine has been left out of the refrigerator for more than 3 days.
If you are not sure if you should be using NEULASTIM, talk to your doctor or pharmacist.
Before you start to use it
Tell your doctor if:
preservatives or dyes
Your doctor will discuss the possible risks and benefits of using NEULASTIM during pregnancy.
Your doctor will discuss the possible risks and benefits of using NEULASTIM while breast-feeding.
∙ a medical condition affecting the bone marrow or blood
∙ a family history of a genetic disorder called acute myeloid leukemia (AML), with cytogenetics t(15;17)
∙sickle cell disease [an inherited disease in which red blood cells are sickle(curved or tapered shaped)]
∙previous problems with your kidneys, liver, heart or other organs
∙previous radiotherapy or chemotherapy treatment for cancer
∙any infections, cancers or tumours.
杨受成 容祖儿If you have not told your doctor about any of the above, do so before you start to use NEULASTIM.
Your doctor will decide whether it is safe for you to use NEULASTIM.
Taking other medicines
Tell your doctor if you are taking any other medicines,particularly those which may affect the blood. Tell your doctor about any medicines or herbal remedies that you have bought from a pharmacy, supermarket or health food shop.
Some medicines may interfere with NEULASTIM.These medicines include some chemotherapy medicines, such as fluorouracil, methotrexate and sulfanilamide.
These medicines may be affected by NEULASTIM or may affect how well it works. You may need to use different amounts of your medicine, or you may need to take different medicines.
Your doctor or pharmacist has more information on medicines to be careful with or avoid while using NEULASTIM.
Ask your doctor or pharmacist if you are not sure about other medicines you are taking.
How to use NEULASTIM
Follow all directions given to you by your doctor,pharmacist or nurse carefully.
They may differ from the information contained in this leaflet.
NEULASTIM can be administered by a doctor, nurse or by patients themselves.
NEULASTIM is given by injection, usually into the tissues just below the skin. This is called a subcutaneous injection and it is a simple procedure.
If you do not understand the instructions, ask your doctor, pharmacist or nurse for help.
Instructions for NEULASTIM pre-filled syringe
This section contains information on how to give yourself an injection of NEULASTIM using the read
y-to-use pre-filled syringe.It is important that you do not try to give yourself the injection unless you have received special training from your doctor or nurse.If you are unsure about anything, ask your doctor or nurse for help.
Things to do before you inject
Make sure that you have all the materials you need for your injection:
∙ a new NEULASTIM ready-to-use pre-filled syringe
∙an alcohol swab
∙ a puncture-resistant sharps container
Follow these instructions exactly to help avoid contamination and possible infection.
1. Find a clean, flat working surface, such as a table, where you can inject undisturbed.
2. Remove the ready-to-use pre-filled syringe from the refrigerator. For a more comfortable injection,
leave it at room temperature for approximately 30 minutes. Do not warm NEULASTIM in any other way (e.g. do not warm it in the microwave or in hot water).Do not leave the pre-filled syringe
exposed to direct sunlight.
3. Do not shake the syringe.Shaking will cause NEULASTIM to clump and it will not work properly.
4. Do not remove the needle cover until you are ready to inject.
5. Check the expiry date on the label. Do not use it if the date has passed the last day of the month
shown.
6. Check the appearance of the solution. The solution should be clear and colourless. If it is cloudy,
coloured or if there are clumps or flakes, you must not use it.漂亮的av女演员
7. You may notice a small air bubble in the pre-filled syringe. You do not have to remove the air bubble
before injecting. Injecting the solution with the air bubble is harmless.
8. Wash and dry your hands thoroughly.
9.While keeping the needle cover on, grasp the needle cap and remove it carefully.
10.Remove the rubber cover from the glass syringe.
11.Connect the needle to the tip of the syringe and fasten it well.You may need to use a bit of force to
do this.
12. Hold the syringe vertically with the needle pointing up –this helps reduce the amount of medicine
that may leak out of the needle.Expel air from the syringe and needle by gently pressing the plunger upwards.
13. With one hand, squeeze firmly on the base of the needle cover with your thumb and forefinger
(while taking care not to break the glass pre-filled syringe).Turn and pull the needle cover off while holding the syringe with your other hand,taking care not to touch the exposed needle.
The pre-filled syringe is now ready to use.
Where to inject
The best injection sites are the front or side of the thighs and the abdomen, except for the area around the navel (belly button). Change the injection site each time you inject to avoid tenderness at any one site.
How to inject
Always follow the instructions of your doctor, pharmacist or nurse -they may be different from those below.
14. Clean the site where the injection is to be made with an alcohol swab, moving the alcohol swab in
an expanding circle and allow the site to dry.
15. Pinch a large area of skin between your thumb and forefinger, without squeezing it.
16. Pick up the syringe and hold it like a pencil.
17. Insert the needle directly into the skin (at an angle of between 45 and 90 degrees or as advised by
your doctor, nurse or pharmacist).
18. After the needle is in, pull back the plunger very slightly.If blood comes into the syringe, the needle
has entered a blood vessel. If this happens, remove the needle, choose a new injection site and repeat steps 13 –16 again.Select another site, clean the new site with an alcohol swab and
reinsert the needle. Again, pull back the plunger very slightly to check for blood.
19. If blood does not appear in the syringe, inject the NEULASTIM by gently pushing the plunger all the
way in, while keeping your skin pinched.
20. Withdraw the needle and using the alcohol swab, apply pressure for several minutes to the
injection site.
21. Do not put the needle cover back on the used needle. You cannot reuse the NEULASTIM pre-filled
syringe.Unless your doctor, nurse or pharmacist advises you of another method of disposal, put the used syringe and needle into an approved, puncture-proof, sharps container.
How much to inject
Use NEULASTIM exactly as your doctor has prescribed.
The usual dose is one subcutaneous injection.
When to inject
NEULASTIM should be injected 24 hours after the end of each chemotherapy cycle. Your doctor will tell you when to begin your treatment and when to stop.
If you forget your injection
If you miss your scheduled dose, tell your doctor, nurse or pharmacist as soon as possible about your missed dose.
In case of an overdose
Immediately telephone your doctor, or the National Poisons Information Centre (telephone 0800 POISON or 0800 764 766), or go to your nearest Accident and Emergency Centre if you think you or anyone else may have had too much NEULASTIM.Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
Keep telephone numbers for these places handy.
If you are not sure what to do, contact your doctor or pharmacist.
While you are using NEULASTIM
Things you must do
Tell all doctors, nurses and pharmacists who are treating you that you are using NEULASTIM. Tell your doctor if you become pregnant while using NEULASTIM.
Be alert for any signs or symptoms of infection.
You should watch out for fever (your body temperature is raised above 37.6°C, or as advised by your doctor), chills, rash, sore throat, diarrhoea, ear ache, difficult or painful breathing, coughing or wheezing.
If you develop any of these symptoms, see your doctor immediately or go to your nearest Accident and Emergency Centre.
Blood tests
Keep all of your doctor’s appointments so that your health can be monitored.
Your doctor may arrange for blood tests to check the levels of infection-fighting neutrophils and other blood cells.
Things you must not do
Do not stop taking NEULASTIM or change the dose without first checking with your doctor.
Do not give NEULASTIM to anyone else,even if they have the same condition as you.
Do not use NEULASTIM to treat other complaints unless your doctor says to.
Do not take other medicines,whether they require a prescription or not,without first telling your doctor or consulting a pharmacist.
Side effects
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are using NEULASTIM, even if you do not think the problems are connected with the medicine or are not listed in this leaflet.
Like other medicines, NEULASTIM may have unwanted side effects.Some side effects may be serious and need medical attention. Other side effects are minor and are likely to be temporary. You may also experience side effects caused by other medicines you are taking at the same time as NEULASTIM.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following and they worry you. Some of these are known side effects of chemotherapy and may not be related to NEULASTIM:
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